Overview
Mepisan Cream (Mepyramine Maleate) is a medicated topical treatment used to manage localized skin reactions and allergies. It belongs to a therapeutic class of drugs known as topical antihistamines. Unlike oral allergy medications that affect the entire body, Mepisan is applied directly to the skin to provide targeted relief from itching and swelling caused by external triggers.
Uses / Indications
Mepisan Cream is primarily used to treat minor skin irritations that result in itching or discomfort. Common indications include:
- Insect Bites and Stings: Reducing the itch and swelling from mosquitoes, bees, or wasps.
- Nettle Rash (Urticaria): Soothing the “prickly” sensation and red bumps of hives.
- Allergic Skin Reactions: Relieving discomfort caused by contact with certain plants or irritants.
- Heat Rash: Calming irritated skin caused by excessive sweating or heat exposure.
Ingredient
The active pharmaceutical ingredient is Mepyramine Maleate.
This is an established antihistamine compound formulated in a gentle cream base. The cream is designed to be absorbed quickly by the skin without leaving an excessively thick or oily residue, making it practical for use on visible areas of the body.
How It Works
When the skin is bitten by an insect or exposed to an allergen, the body releases a chemical called histamine. Histamine is responsible for the redness, itching, and inflammation we feel.
Mepisan Cream (Mepyramine Maleate) works as a histamine antagonist. It effectively “plugs” the histamine receptors in the skin cells. By blocking these receptors, the cream prevents the histamine from triggering the inflammatory response. This leads to a rapid reduction in the urge to scratch and helps the localized swelling subside.
Dosage & Administration
For the best results, Mepisan should be applied as soon as the irritation occurs:
- Application: Apply a small amount of cream directly to the affected area.
- Frequency: It is typically used two to three times daily.
- Duration: Use the cream for a few days until the symptoms clear up. If symptoms persist for more than three days, a medical consultation is recommended.
- Hygiene: Always wash your hands before and after applying the cream to avoid spreading irritants.
Possible Side Effects
While Mepisan is safe for most users, some mild side effects may occur:
- Skin Sensitivity: A temporary stinging or burning sensation upon application.
- Photosensitivity: In rare cases, treated skin may become more sensitive to sunlight.
- Allergic Dermatitis: Occasionally, a person may be sensitive to the antihistamine itself, resulting in increased redness or a rash.
Precautions & Warnings
- Broken Skin: Do not apply Mepisan Cream to raw, weeping, or broken skin.
- Eczema: Avoid use on areas of skin affected by acute eczema or other chronic skin conditions unless directed by a doctor.
- Eyes and Mouth: Avoid contact with sensitive mucosal areas. If contact occurs, rinse thoroughly with water.
- Pregnancy: If you are pregnant or breastfeeding, it is best to consult a healthcare professional before using medicated topicals.
- Usage Limit: Do not use over very large areas of the body for extended periods.
Frequently Asked Questions
Can Mepisan Cream be used on children?
Mepisan is generally suitable for older children, but for infants and very young children, you should consult a pharmacist or pediatrician before use.
Does this cream stop the pain of a bee sting?
While it is excellent for the itching and allergic swelling, it is an antihistamine rather than a local anesthetic. It will significantly reduce the irritation that follows the initial sting.
Can I use this for a fungal infection?
No. Mepyramine Maleate only treats allergic reactions. It does not have antifungal or antibacterial properties.
Conclusion
Mepisan Cream (Mepyramine Maleate) is a versatile addition to any first-aid kit, offering a direct way to calm the skin’s response to environmental irritants. Blocking histamine at the source, it provides the comfort needed to allow the skin to heal naturally without the interference of constant scratching.



