Introduction
Aquaclav 375 mg is a combination antibiotic medicine. It contains two active agents: amoxicillin and clavulanic acid. This pairing helps extend the antibiotic spectrum and improve efficacy against bacteria that would otherwise resist standard amoxicillin alone.
Aquaclav 375 mg is commonly prescribed for a variety of bacterial infections involving the respiratory tract, urinary system, skin and soft tissues, ear/nose/throat, and dental infections. Because it combines a beta-lactam antibiotic (amoxicillin) with a beta-lactamase inhibitor (clavulanate), it can overcome certain types of bacterial resistance.
Uses of Aquaclav 375 mg
Aquaclav 375 mg is used to treat infections caused by susceptible bacteria. Some of the common indications include:
- Respiratory tract infections: bronchitis, pneumonia, sinusitis, tonsillitis, and middle ear (otitis media) infections
- Ear, Nose & Throat (ENT) infections
- Urinary tract infections (UTIs) — such as cystitis or pyelonephritis
- Skin and soft tissue infections: cellulitis, abscesses, wound infections
- Dental or oral infections: e.g., dental abscess
Other infections where the causative bacteria produce beta-lactamase enzymes, making them less responsive to simple penicillins
Because clavulanic acid helps block bacterial enzymes that degrade amoxicillin, Aquaclav 375 mg is more effective than amoxicillin alone against many resistant bacteria.
Ingredients (Composition)
Each Aquaclav 375 mg tablet contains:
Amoxicillin (in the form of amoxicillin trihydrate) — typically 250 mg
Clavulanic acid (as potassium clavulanate) — typically 125 mg
How It Works (Mechanism of Action)
Aquaclav’s action is based on combining two complementary agents:
Amoxicillin is a beta-lactam antibiotic. It works by inhibiting bacterial cell wall synthesis. Specifically, it binds to penicillin-binding proteins (PBPs) inside the bacterial cell wall. This prevents the cross-linking of peptidoglycan chains, weakening the cell wall and leading to bacterial lysis (rupture) when the bacteria try to grow or divide.
Clavulanic acid is not an antibiotic by itself, but a beta-lactamase inhibitor. Some bacteria produce enzymes called beta-lactamases that can break down (hydrolyze) amoxicillin (and other penicillins), rendering them ineffective. Clavulanic acid binds to and inhibits many of these beta-lactamase enzymes, thus protecting amoxicillin from destruction. This expands the spectrum of bacteria against which the combination is effective.
Together, these dual mechanism enables Aquaclav to kill or inhibit bacteria that would ordinarily resist amoxicillin alone.
Dosage (Recommended Use)
Important: The following are only general guidelines. Always follow your doctor’s or pharmacist’s instructions and local prescribing recommendations. Factors such as age, kidney function, severity of infection, and the specific organism may influence the exact dose.
Adults and adolescents (over 12 years / > 40 kg body weight):
- Typical dose: 1 tablet of 375 mg taken twice daily (i.e., one in the morning, one in the evening), or as directed.
In more severe infections, a more frequent dosing regimen (e.g., three times daily) may be used, depending on clinical judgment.
Children:
- Dosing is typically weight-based (mg per kg body weight). Pediatric specialists or guidelines will define the appropriate dose and frequency.
- The 375 mg tablet may not be appropriate for small children; a liquid suspension or lower strength preparation is often preferred.
Special populations:
- Renal impairment (kidney problems) may require dose adjustment or extended dosing intervals.
- Liver impairment — use cautiously; monitor for signs of liver toxicity.
- Elderly — may require monitoring, especially if comorbidities are present.
Duration of treatment:
Usually 5 to 14 days, depending on infection severity, site, and response.
Even if symptoms improve, complete the full prescribed course unless told otherwise, to help prevent antibiotic resistance or relapse.
When to take:
Often taken at the start or during meals to reduce gastrointestinal upset and improve absorption.
Side Effects
As with all medications, Aquaclav 375 mg may cause side effects. Many people tolerate it well, but you should be aware of potential adverse reactions.
- Diarrhea
- Nausea
- Vomiting
- Abdominal discomfort or pain
- Indigestion, dyspepsia
- Skin rash, itching
If you experience unusual bleeding, persistent severe diarrhea, yellowing of eyes/skin, or signs of allergic reaction, stop the drug and contact your physician immediately.
Frequently Asked Questions (FAQs)
1. Is Aquaclav 375 mg the same as Augmentin 375?
Yes, therapeutically they are equivalent in the sense that they both contain amoxicillin + clavulanic acid. The exact brand names differ by region. The 375 mg refers to the combined strength, often 250 mg amoxicillin + 125 mg clavulanate.
2. Can it treat viral infections like the common cold or flu?
No. Aquaclav is an antibiotic that is only effective against bacterial infections. It does not work against viruses such as those causing colds, flu, or most sore throats of viral origin.
3. What if I forget a dose?
Take the missed dose as soon as you remember, unless the next scheduled dose is near. Do not double-dose to catch up. When in doubt, skip the missed dose and continue your normal schedule.
4. Can I drink alcohol while on Aquaclav?
While there’s no strong direct interaction, consuming alcohol may increase the risk of liver side effects or gastrointestinal upset. It’s generally safer to avoid excessive alcohol consumption during antibiotic therapy.
5. Is it safe in pregnancy or while breastfeeding?
It may be used in pregnancy or lactation if clearly needed, but only under medical advice. The benefits and risks must be weighed by a physician.
6. Can Aquaclav cause antibiotic resistance?
Yes. Misuse, overuse, or stopping early can encourage resistant bacteria. Always complete the full prescribed course and use the drug only when prescribed.
7. Will it affect oral contraceptive pills?
Antibiotics like amoxicillin/clavulanate are not known to significantly reduce the effectiveness of hormonal contraceptives, but for safety, some physicians recommend using additional barrier methods during the antibiotic course.
8. Where can you buy Aquaclav in Nigeria?
Buy Aquaclav online at Drugstore.ng, Nigeria’s largest online pharmacy store
Conclusion
Aquaclav 375 mg is a robust antibiotic combination (amoxicillin + clavulanic acid) designed to treat a wide range of bacterial infections, especially where resistance may be an issue. Its dual-action mechanism helps it overcome many bacterial defense strategies. When used appropriately — at the right dose, duration, and under medical supervision — it is generally safe and effective.
However, like all antibiotics, it must be used responsibly. Always follow your healthcare provider’s instructions, complete the full course, and be alert for side effects or allergic reactions. If you experience any worrying symptoms, seek medical advice immediately.
